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Potential patients are warned GLP-1 drugs can cause side effects including nausea, diarrhoea, constipation and vomiting, and lead to more serious problems such as kidney damage

This effect has contributed to its notable impact on weight loss, though in the UK it is primarily licensed for diabetes management rather than obesity treatment alone (though a higher-dose formulation, Wegovy, is available specifically for weight management)

These variants do not predict exact medication response but may provide context for why some individuals show different baseline weight, glucose metabolism, or appetite regulation patterns

Rushing this schedule increases gastrointestinal side effects

Interestingly, both estradiol and leptin receptors colocalize in kisspeptinergic neurons, which are considered to be the link between nutrition (metabolism) and reproduction (ovulatory function) (151)