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doi: 10.1186/s12933-021-01409-0

However, these medications have their own side effects and are typically reserved for cases where other approaches fail

The activation of the GIP receptor by tirzepatide contributes to its effectiveness in a few ways: Enhanced Insulin Secretion : Similar to GLP-1, GIP promotes insulin secretion in response to high blood sugar
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Some vials dissolve quickly
The buccal mucosa is thicker than the sublingual tissue, typically 500 to 800 micrometers, which means drug penetration takes longer

These problems get better as blood sugar evens out
