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Some at-home cold sore remedies include: Applying cold sore ointments such as Docosanol (Abreva) to shorten outbreaks Using zinc oxide cream or a lip balm with sunblock to protect your lips Applying a cool compress (such as a cold, wet washcloth) to reduce redness, help remove crusting, and promote healing Using over-the-counter products such as pain relievers, creams with lidocaine or benzocaine, or remedies that contain a drying agent (i.e., alcohol) Drinking plenty of fluids Applying topical amino acid supplements such as lysine Using propolis, a synthetic beeswax available as a 3% ointment, to shorten the duration of symptoms Applying a cream that combines rhubarb and sage, which may be as effective as acyclovir (Zovirax) cream Reducing stress, since stress can cause or worsen symptoms Soothing the skin with aloe vera gel, which contains anti-inflammatory properties Because there is insufficient evidence to support the use of at-home cold sore remedies, be sure to discuss any treatments with your doctor before use