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Several well-established and widely prescribed GLP-1 receptor agonists, including various formulations of semaglutide, liraglutide, and dulaglutide, are administered via subcutaneous injection

These two pathways are connected by focusing on mitochondrial homeostasis and the cellular response to stress, specifically oxidative stress and mitochondrial damage

A total of 9340 participants with a high CV risk, who were 50 years of age, with HbA1c 7% were randomly assigned to receive placebo or liraglutide (1.8 mg)

GLP-1RAs act via a multitude of mechanisms in the gut and the pancreas

The above studies suggest that GLP-1RAs may be a valuable strategy for the treatment of atherosclerosis (Figure 1) (Table 3)

Al-SadawiMAslamFAleemSAlsadaoeeMStevensGASinghAet alAssociation of glp-1 agonists with arrhythmias and sudden cardiac death in patients with type 2 diabetes: a meta-analysis of 27 randomized controlled trials