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The addition of glucagon receptor agonism to the GLP-1/GIP dual mechanism significantly increases energy expenditure and fat oxidation, producing weight loss potential that exceeds even tirzepatide

doi:10.1001/archpsyc.65.4.466 Squeglia LM, Tomko RL, Baker NL, Kirkland AE, McClure EA, Gray KM

They raise blood glucose quickly and can worsen nausea or bloating on GLP-1s, especially when digestion is already slowed

Empagliflozin Empagliflozin (Jardiance) was approved for the treatment of people with T2D by the EMA and the FDA in 2014

However, this popularity has caused a shortage of Ozempic, earning Novo Nordisk significant financial gains

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