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Clinical Trials of Retatrutide and Their Results The clinical trials for Retatrutide focus on evaluating its effectiveness in weight loss and treating metabolic diseases such as type 2 diabetes and obesity

6b, Table 2)

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GLP-1 Receptors Exist Throughout the Body Although GLP-1 medications work in the pancreas to regulate insulin and glucagon, GLP-1 receptors are widely distributed in other areas of the body, including the brain, cardiovascular system, immune system, gut, and kidneys, says Diana Isaacs, PharmD, CDCES, an endocrine clinical pharmacy specialist in the Endocrine and Metabolism Institute at Cleveland Clinic in Ohio

Liraglutide (Saxenda, Victoza): Typically results in a more modest weight loss, with patients losing about 58% of their body weight over a year

This is significant because visceral fat drives insulin resistance, inflammation, and cardiovascular risk to a degree that subcutaneous fat does not