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Hypothalamic GIPR signaling is not required for the additive effects of GIPR and GLP-1R agonism in inducing weight loss, and the GIP receptor is expressed by several cells in the hypothalamus and brainstem that can extinguish appetite
The results of direct and indirect treatment comparisons in metaanalysis of randomized controlled trials
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The GIP receptor activation provides additional metabolic benefits through pathways that pure GLP-1 agonists like semaglutide simply cannot access
[DOI] [PubMed] [Google Scholar] 12.Sterne JAC, Savovi J, Page MJ, et al
