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If the drug has too strong an effect in the lower intestine, slow GI motility leads to constipation, he said

These contractions are driven by prostaglandins natural chemicals that trigger inflammation and muscle tightening
Beyond mechanical effects, emerging evidence suggests GLP-1 receptor agonists may exert anti-inflammatory properties that could theoretically benefit joint health
Bailey CJ, Iqbal N, TJoen C, List JF

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