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Common reasons include side effects (particularly nausea and vomiting), cost of ongoing private prescription, insufficient weight loss at tolerated doses, or switching to Mounjaro after learning about the SURMOUNT-5 trial results showing tirzepatides greater average efficacy

A 2025 JAMA Network Open cohort study found that most patients with overweight or obesity stopped dual-labeled GLP-1 receptor agonist therapy within 1 year

This caused him to gain some weight, and hes now at 210 pounds, but its more muscle. His diet has changed, too, and he focuses on counting macronutrients