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3 Discussion Eighty-two participants, who continued with 14 mg oral semaglutide (the highest dose registered for managing type 2 diabetes) for one year experienced a significant average weight loss of 5.7% (5.9 kg), along with a reduction in BMI by an average of 2 kg/m

Animals have been used in a large number of in vitro and in vivo toxicity studies, but there have only been a small number of human investigations

That trial supports a 2024 FDA label expansion making semaglutide indicated for cardiovascular risk reduction in adults with overweight or obesity and prior CV disease
