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For those particularly sensitive to the medication, your provider may suggest an approach that prioritizes using the lowest effective dose for achieving the targeted weight loss instead of increasing to the 15mg weekly dose
In a multicenter open-label randomized controlled trial, exenatide alone or in combination with basal insulin showed to be safe and effective for the management of hyperglycemia when compared with basal-bolus insulin regimen in 150 hospitalized general medical and surgical patients with type 2 diabetes

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Extra sugar in your blood gets stored as fat, resulting in weight gain

Fat Metabolism : GIP can reduce circulating triglycerides when used therapeutically