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These dose-dependent effects include reductions in: inflammatory pathway activations proinflammatory cytokine and collagen degradation enzyme expressions mitochondrial dysfunction oxidative stress According to the above review, all three studies highlighted that GLP-1 analogs may work to treat RA by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells pathway, which can improve immune responses

[DOI] [PubMed] [Google Scholar] 2.Costa L, Ramonda R, Ortolan A, Favero M, Foti R, Visalli E, et al