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In patients with T2D, when analyzed separately, semaglutide and tirzepatide were associated with a greater reduction of HbA1c and FPG compared to other agents, producing a T2D remission (discontinuing pharmacological treatment) in a relevant proportion of cases

This dehydration risk is the primary concern prompting temporary metformin discontinuation

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This direct measurement is key to optimizing the retatrutide timing post tirzepatide research cycle

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