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Digestive enzymes Alpha-galactosidase (sold as Beano) specifically breaks down the complex sugars in legumes and cruciferous vegetables that your body cannot digest on its own

This sets up a regulatory fragmentation nightmare

Consider digestive enzymes with meals if fat digestion seems problematic

Rare variants in genes linked to appetite control and hypothalamic development in early-onset severe obesity

[DOI] [PMC free article] [PubMed] [Google Scholar] [36].Gupta S, Afzal M, Agrawal N, Almalki WH, Rana M, Gangola S, et al

Whether it's being degraded in the gastric acid, or prematurely being activated in the stomach and not absorbed in the small intestine due to delayed gastric emptying from GLP-1 therapies