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A phase 2b placebo-controlled randomized trial (EMMINENCE) failed to show improved histological outcomes ( 2-point NAS improvement without worsening fibrosis, NASH resolution, and fibrosis reduction) among patients with biopsy-proven NASH and stage 13 fibrosis [70]

doi: 10.1111/1751-7915.12778 Summary Keywords MOTS-c, mitochondrial-derived peptide, therapeutic exploitation, synthetic biology, endocrine Citation Zheng Y, Wei Z and Wang T (2023) MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation

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