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A gradual titration schedule is commonly used to help reduce initial discomfort and improve adaptation

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Study procedure (Koide et al., 2025) GLP-1RA therapy significantly reduced blood glucose levels, body weight, and body fat percentage Results showed that after 12 months of treatment, GLP-1RA therapy significantly reduced participants blood glucose levels (as measured by glycated hemoglobin), body weight, and body fat percentage

Clinicians and patients should consult these documents rather than relying on general statements about class effects

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