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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Wong MH, Oelkers P, Dawson PA

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Recent studies on long-acting GLP-1s in type 1 diabetes have shown promising results, including reductions in A1C levels and increased time within the target blood sugar range, without diabetic ketoacidosis or significant hypoglycemic episodes.It is well-established that elevated A1C levels can increase the risk of cardiovascular complications and kidney disease in individuals with T1D

The activation of the GIP receptor in the arcuate, dorsomedial and paraventricular nuclei of the hypothalamus decreased food intake in obese mice

others (like a tri-agonist by Pfizer) are in mid-stage trials

Accompanied by neurologic symptoms such as leg weakness, numbness, bowel or bladder dysfunction, or saddle anesthesiathese are red flags for cauda equina syndrome or severe nerve compression requiring emergency evaluation