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A small 2023 observational study found evening injectors reported 30% lower headache severity scores than morning injectors, though total incidence was similar

Theres also a small click when the dose has been injected

Rubbing disperses the medication unpredictably, increases bruising, and can worsen injection site reactions

[10] [14] Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which are generally mild to moderate and diminish over time

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Heat increases the rate at which these amino acids react with oxygen in the solution, creating oxidized variants that bind receptors poorly or not at all