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Variants in GLP1R, GIPR, FTO, and MC4R genes may help provide context for your provider's clinical decision-making around whether tirzepatide is appropriate and at what dosing strategy to begin

doi: 10.1093/ajhp/60.4.356

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Central nervous system involvement is further supported by GLP-1 production in caudal brainstem neurons, key integrators of vagus nerve-mediated gut-brain signaling 53,54,55,56