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If you are not drinking enough water, your urine becomes more concentrated

While single-dose or short-term studies may demonstrate acceptable safety, the long-term consequences of daily or weekly tissue penetration over years of chronic therapy remain to be characterized
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If hormonal birth control does not work as well, hormone levels might change, leading to breakthrough bleeding or changes in the menstrual cycle

In other words, sometimes trial participants do report a certain symptom, but researchers may conclude its not significant because people taking a placebo (dummy treatment) have the same experience

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