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Rapid weight loss has long been associated with biliary disease, sarcopenia, and alopecia [170,171,172,173,174]

The power of this approach is further emphasized in that the (4 + 3) annulation strategy is revealed to be an effective means with which to generate novel TRPA1 channel activators

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The underlying mechanism is not fully understood, but it's theorized that these drugs may alter pancreatic enzyme levels or cause changes in ductal cells, leading to pancreatitis in susceptible individuals