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However, despite their widespread use, some aspects of GLP-1 function, especially pertaining to its role in the central nervous system (CNS), remain unexploredan important gap considering the increasing number of patients receiving this treatment (22, 23)

Here, we will provide an overview of the existing literature around diabetes and metabolism in the context of cancer and cachexia

Lancet Diabetes Endocrinol 7(8):596605

While patients are usually born at a normal weight, genetic differences affecting hunger regulation, satiety, and metabolism can lead to rapid weight gain

Clinical Correlates: Oral Adverse Effects Real-world pharmacovigilance studies suggest that semaglutide is disproportionately associated with gastrointestinal adverse events compared to other GLP-1Ras [10,11]

Many patients turn to tirzepatide for weight loss injections as part of a medically supervised program