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35 The incidence of hypoglycaemia was also significantly reduced at week 24

2014, 13:142 GLP-1R Signaling Binding of GLP-1 to GLP-1R triggers a downstream signaling cascade that induces a potent stimulation of glucose induced insulin secretion (GIIS) in pancreatic beta-cells, as well as inhibition of alpha cell glucagon release (6)

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For example, in 2023, the European Medicines Agency began investigating over 150 reports of suicidal ideation and other psychiatric symptoms linked to GLP-1 receptor agonists, including Ozempic and Wegovy