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The semaglutide and tirzepatide trials changed that expectation: Semaglutide 2.4 mg once weekly produced average weight loss around 15% at ~68 weeks in adults without diabetes, with a substantial fraction of participants losing 1520% of baseline weight

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Lean Mass Vulnerability and Anabolic Suppression GLP-1RA therapy is frequently associated with reductions in lean body mass in clinical studies [40], although preclinical experiments have reported improvements in muscle function and mass under certain conditions [41,42,43]

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