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Pharmacol Biochem Behav 2002;71:53354

In a controlled crossover feeding study, a high-GI meal selectively increased activation in reward and craving regions four hours postprandially compared with an isocaloric low-GI meal, independent of palatability [26]

For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period

Desensitization and Receptor Trafficking Most agonist-activated GPCRs undergo rapid desensitization through a coordinated two-step process: first, phosphorylation of the receptor by GRKs, and second, recruitment of -arrestins to these phosphorylated sites, which sterically block further G-protein coupling [54]

These data provide a potential mechanism by which central GLP-1 receptor stimulation modulates parasympathetic outflow to the heart and increases heart rate

It is important to note that whilst these findings are promising, there is no official consensus on GLP-1 receptor agonists being prescribed specifically as anti-inflammatory agents