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The supernatant was analysed by LC-MS

Adding semaglutide on top creates additive hypoglycemia risk

Due to the lack of phenotypic differences in metabolic parameters within the control lines (20), we present data for control mice (aggregate of mice expressing Cre ( Vil1 -Cre for Dpp4 Gut/ and Tie2 -Cre for Dpp4 EC/ ) and Dpp4 fl/fl mice (littermate controls from the corresponding line) versus mice with the 2 different targeted Dpp4 deletions

Results were dose-dependent, with lower doses producing more modest reductions
