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Rybelsus is the first oral GLP-1 receptor agonist and requires specific administration: it must be taken on an empty stomach with up to 120ml of water, swallowed whole, and followed by at least 30 minutes before eating, drinking or taking other oral medications

Diabetologia (2017) 60(9):180112
However, as the effects do not persist over an entire 24 h period, its efficacy at lowering blood glucose levels and reducing body weight is lower than that of GLP-1 receptor agonists with a longer duration of action [3]
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Scott JW, van Denderen BJ, Jorgensen SB, Honeyman JE, Steinberg GR, Oakhill JS, et al

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