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An editorial review of Agile Health business model, compounded-pharmacy pathway, patient reports, and fair-balance safety

Will GLP-1s remain dominant, or will new innovations emerge

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Lilly Koreas diabetes drug Trulicity grabbed the largest market share in Korea, ahead of archrival Novo Nordisk and their blockbuster diabetes drug Victoza, amid heated competition and pricing pressures in the diabetes market

Conclusions Hypomorphic PAM T2D-risk alleles reduce amidating enzyme activity, elevate circulating GLP-1 levels, and impair GLP-1 post-receptor signaling, culminating in a selective and clinically meaningful reduction in GLP-1RA efficacy

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