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Description
GLP-1/antisense conjugates have been developed to bypass a refractory nature of pancreatic -cells to the uptake of antisense oligonucleotides while harnessing the untapped potential of these oligonucleotides to repress the expression of pathological intracellular targets [951]

[1] Common adverse effects include nausea, vomiting, diarrhoea, and injection site reactions

NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes

Role of GLP-1 in Tackling Obesity: GLP-1 receptor agonists are designed to mimic the effects of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1)

doi: 10.1056/NEJMoa1901118 44 GersteinHCSattarNRosenstockJRamasundarahettigeCPratleyRLopesRDet al

Insulin resistance promotes ovarian androgen excess and disrupts folliculogenesis
