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When he began the trial, he weighed about 260 pounds, with a body mass index of around 32, and hoped to get closer to 200 pounds

The rapid drop in weeks 1 to 2 is largely water and glycogen, not fat

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Studies have shown that many people regain a lot of the lost weight within months of stopping, especially if they go back to old eating patterns
These receptors promote downstream pathways that are important for appetite regulation, insulin sensitivity, and metabolism, among other benefits, and so lead to improvements in weight and metabolic health. Ali adds that the stimulation slows stomach emptying, increasing the chance a patient is satiated longer (and therefore eats less)

Chen J, Zhao H, Ma X, Zhang Y, Lu S, Wang Y, et al