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The high molecular mass of GLP-1s suggests that transfer across the placenta wouldnt be expected, but given the lack of knowledge, women using them for weight loss (who do not have diabetes) are advised to stop before trying to conceive

But what exactly are they, and should women over 50 consider them

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Lancet 383(9918):736747 [DOI] [PMC free article] [PubMed] [Google Scholar] 18.Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A (2008) Sleep apnea and cardiovascular disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement

With the rapid increase in the population of obese individuals , obesity has become a global problem with significant implications for public health, including increased risk of diabetes, cardiovascular disease, and other comorbidities

Short-acting GLP-1 agonists like exenatide (taken twice daily) may produce more immediate effects on post-meal glucose levels, whilst longer-acting weekly formulations such as semaglutide or dulaglutide provide more sustained action but may take longer to reach steady-state concentrations in the body