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Why GLP-1s are Biologically Plausible for Alzheimers Beyond lowering glucose and weight, GLP-1 signaling appears to: Improve insulin signaling in the brain Dampen neuroinflammation (microglial activation) Reduce oxidative stress Interact with amyloid- and tau pathways in preclinical models Recent peer-reviewed reviews synthesize these mechanisms and frame GLP-1s as potential multi-target neuroprotective agents rather than single-pathway drugs

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Diabetes 63 (4), 12241233

[DOI] [PubMed] [Google Scholar] 11.Kosteli A., Sugaru E., Haemmerle G., Martin J.F., Lei J., Zechner R., Ferrante A.W., Jr

Moreover, while effective for some, biologics often fail to achieve sustained disease control and are associated with significant costs, potential side effects, and limited accessibility in some regions [6]