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Rare but serious effects (0.11.2%) for both agents include bone marrow suppression (neutropenia, agranulocytosis, eosinophilia, leucopenia)

The proportion of individuals with weight loss above 5% was also higher for tirzepatide (6580%) than for SMG (54%)
S., Hafermann, J

Gastro-oesophageal reflux, a known side effect of Saxenda, could theoretically contribute to throat irritation in susceptible individuals

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2014 [cited 2025 Nov 12];40:16070
