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Lancet 2017;389:1399409.ArticlePubMed 12

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Interestingly, glucagon-like peptide-1 receptor agonists (GLP-1RAs), used in the treatment of T2DM and obesity, are known to show pro-cognitive and neuroprotective properties, and exert modulatory effects on immune, endocrine and metabolic processes in the central nervous system

Thyroid dysfunction, leptin resistance, and autoimmune disease can stem from untreated inflammation: The connection between thyroid disease and PCOS is very important because hypothyroidism makes all of the symptoms of PCOS worse and there is an emerging relationship between these two conditions in the literature (7)

Clment K, van den Akker E, Argente J, et al

We can see worsening in cardiometabolic parameters, including glucose levels, that may occur even before significant weight regain
