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This is not the medication failing

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Advancements in stem cell therapy, namely pancreatic islet transplantation, have been noted, with recent trials demonstrating insulin independence in 60% of recipients after five years

It tends to be transient, often resolving within a week of onset, and is more likely if you consume high-fat or high-sugar foods

Skipping doses or starting higher increases the risk of severe nausea, vomiting, and other gastrointestinal side effects that could derail the entire switch

It should state the clinical justification for using a compounded drug, such as the unavailability of the FDA-approved product due to a shortage