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2023 NEJM) found semaglutide reduced overall cardiovascular event rates by 20% despite the small HR increase

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The loss of intermediates through efflux from the TCA cycle, called cataplerosis, must be resupplied, mainly by glutamine metabolism in a process known as anaplerosis

For example, if a patient is managing hypertension and diabetes, their clinician can adjust their weight management plan considering how GLP-1s may affect blood pressure medication and how it can improve their A1C levels

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