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Earlier this year, Veru reported that stair climb power declined by 10% for 42% of older adults with just 16 week on semaglutide in its Phase 2b study an androgen receptor agonist (enobosarm)

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a systematic review and meta-analysis found that after discontinuation of GLP-1 receptor agonists like semaglutide, weight regain occurs at an average rate of 0.4-0.8 kg per monthfour times faster than with behavioral weight management programswith participants often returning to near-baseline weights within 1.5-1.7 years and cardiometabolic benefits reverting to baseline within about 1.4 years, underscoring the need for prolonged therapy combined with lifestyle changes