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The small increased risk of gallbladder problems with Wegovy (2.5% vs 1% with placebo) should be viewed in context

If electrolyte supplementation brings noticeable relief within two to three days, electrolyte depletion was likely your primary fatigue driver

10.1016/S0140-6736(21)01921-8 55

These concentrations allow for practical injection volumes at each dose level in the titration schedule

Nature Medicine 288995
