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A number of agents have been previously trialed including diazoxide [55], metformin in combination with fenofibrate (a peroxisome proliferator-activated receptors alpha activator) [56]

Under diabetic and neurodegenerative conditions, excessive reactive oxygen species (ROS) productionpartly due to elevated levels of advanced glycation end products (AGEs)leads to oxidative damage, mitochondrial dysfunction, and neuronal death

Abstract Background: Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) as well as glucagon-like peptide-1 (GLP-1) have independently been implicated in irritable bowel syndrome (IBS) pathophysiology