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Second, GLP-1RAs reduce neuroinflammatory changes in preclinical models

Mild nausea at 1 mg becomes moderate nausea at 2 mg and potentially severe nausea at 4 mg

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While enzymatic DPP-4 may be more closely related to obesity-associated inflammation and glucose regulation, soluble DPP-4 may have a distinct role that is not associated with inflammation

However, at pharmacological concentrations achieved with therapeutic GLP-1 receptor agonists (100 pM10 nM), -arrestin-2 becomes essential for sustained signaling, specifically mediating extracellular signal-regulated kinase (ERK) activation and CREB phosphorylation that promotes pancreatic -cell survival and insulin synthesis