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In HF with preserved ejection fraction and mildly reduced ejection fraction, semaglutide improved symptoms, physical function, natriuretic peptide levels, echocardiographic parameters, and HF hospitalizations, as shown in the STEP-HFpEF program and a pooled analysis of trials

Potassium Replacement Oral: Preferred if mild and patient can tolerate IV: Severe hypokalemia or unable to take orally Max peripheral IV rate: 10 mEq/hr (with ECG monitoring) Central line: up to 20 mEq/hr in critical cases 3

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