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Lastly, Frssing et al

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Cold intolerance has emerged as a reported side effect in patients taking tirzepatide, the active ingredient in Mounjaro and other GLP-1 receptor agonist therapies

When given to DIO mice, both peptides led to significant weight reduction, improved glucose tolerance, increased energy expenditure, and reductions in plasma cholesterol and liver steatosis

Brain GLP-1/IGF-1 signaling and autophagy mediate exendin-4 protection against apoptosis in Type 2 diabetic rats

If you need additional blood sugar control after one week at the 1.2 mg dose, your healthcare provider may increase your dose to 1.8 mg daily
