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In DIO mice and obese monkeys, AMG133 decreases fasting insulin levels, but this effect was not seen in the clinical trial of AMG133 (84)
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Nonexpression of GLP-1R is common in advanced pancreatic tumors with lymphatic metastasis and is associated with poor prognosis, suggesting that GLP-1R may inhibit tumorigenesis and metastasis of human pancreatic cancer cells both in vitro and in vivo
