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Zepbound produces higher average weight loss based on clinical trial data

The 2 mg injectable dose is orders of magnitude lower than oral therapeutic doses, though subcutaneous bioavailability is higher than oral bioavailability

Staying at an ineffective dose wastes time and can erode confidence in the therapy itself

Elevated valuation of Eli Lilly shares

The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP), [2] [3] [4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels

A patient living with diabetes who is also trying to quit smoking might reasonably choose a GLP-1 drug over another glucose-lowering medication, not because it is approved for smoking cessation, but because it may help them quit, a benefit that other diabetes drugs do not offer