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Phentermine has a short half-life (about 19-24 hours), so it clears your system within a few days of the last dose

Moreover, activation of GLP1 receptor expressing neurons in the paraventricular hypothalamic nucleus reduced dark cycle food intake and refeeding after an overnight fast (Table 1) (Li, Navarrete, et al., 2019)

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Singh, Jeffrey Caplan, Justin J

If you are experiencing severe or persistent diarrhea at a given dose level, extending that dose period from 4 weeks to 6 or even 8 weeks before escalating is a legitimate strategy