do not combine dpp-4 inhibitor with glp-1 receptor agonist guideline Mechanisms of dipeptidyl peptidase‐4 (DPP‐4) inhibitors, glucagon‐like Can patients take GLP-1 and

34 Equally, the GLP-1 mimetics exenatide, dulaglutide, liraglutide, albiglutide, and semaglutide helped preserve bone density and reduce fracture risk in older adults with T2D

Diabetes Obes Metab 26: 54745478

It directly stimulates pro-opiomelanocortin/cocaine-and-amphetamine-regulated transcript (POMC/CART) neurons and indirectly inhibits neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons through GABA neurotransmission, reducing appetite and promoting weight loss [40]

Brain Inj

This triple agonist has demonstrated superiority to dual coagonists (GLP-1R/GIPR) and mono-agonists (GLP-1) in reducing body weight (reduction of 25% in 4 weeks), improving glycemic control, and reducing hepatic steatosis in rodent models

In support of this, when insulin is infused to healthy individuals without diabetes to levels observed in patients with T1D on insulin treatment, insulin sensitivity decreases (36)