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These next-generation agents engage not only GLP-1 receptors but also those for other gastro-entero-pancreatic hormones such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, amylin, and peptide YY to enhance energy uptake, storage, and expenditure through synergistic mechanisms

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If continued assistance is needed beyond that, youll need to reapply annually and provide updated documentation to confirm ongoing eligibility

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Restraints - High Cost of Therapy The high cost of therapy is a significant restraint for the GLP-1 receptor agonist market, limiting patient access and long-term adoption

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These benefits, along with already widespread use and generally good tolerability profile, have piqued interest in the potential benefit of SGLT2i and GLP1-RA in patients with rheumatologic conditions, who are at higher risk of cardiovascular and renal complications

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