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Description
Retatrutide adds glucagon receptor agonism to the GLP-1 and GIP targets already covered by tirzepatide, which is hypothesised to further stimulate hepatic fatty acid oxidation and lipid clearance
Cardiovascular benefit for GLP-1RAs was shown in 2016 for liraglutide in the LEADER trial and semaglutide in the SUSTAIN 6 trial

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