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Research shows these medications can lead to roughly 1022% average body weight loss over about one year , depending on the medication and dose

McMurray JJV, Solomon SD, Inzucchi SE, et al

A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II) Obesity (Silver Spring) 2013;21(5):935943

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