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Importantly, these medications carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

For patients with hypertension, this may translate into reduced cardiovascular risk, though antihypertensive medications should not be discontinued without medical supervision

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[16] Additionally, PCOS is associated with increased cardiovascular risk factors including dyslipidaemia, hypertension, and endothelial dysfunction